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A recording of the presentation titled "Applying the Target Trial framework to routine data: pre-analysis challenges" delivered at the NIHR Statistics Conference in June 2025 by Matthew Franklin (University of Sheffield, UK), Amy Chang (University of Sheffield, UK), and David Lugo Palacios (London School of Hygiene and Tropical Medicine, UK).
The presentation covers the experiences and challenges of the presenters when applying the Target Trial framework to routinely collected care data, mainly covering mental health (Matthew, NIHR Target Trials in Mental Health programme) and cancer (David, NIHR SORT project; Amy, ReCREATE Group) routine data.
Twelve key areas are discussed: Metadata, Directed Acyclic Graphs, Statistical Analysis Plans, third-party data providers, sample size, benchmarking criteria, use of data extracts vs secure data environments (SDEs), risks for PhD students, pilot analyses, timing to get data, convincing funders, and costs.
Unlocking Data for Public Health Policy and Practice: An Introduction to the Benefits and Nature of Sharing Real-World Data for Public Benefit
This 15 minute recording is intended to provide an introduction to what is meant by key words associated with the use of 'real-world data', such as what is real-world data (with a focus on electronic health records and administrative data), direct care compared to secondary uses of such data, and what public benefits can be achieved from sharing such data.
The video was recorded during the 'Open Research Conversations' seminar series, and is therefore intended for a general public audience with little to no previous knowledge about real-world data.
This video is based on the NIHR Public Health Research (PHR) funded Unlocking Data project (NIHR133634).