Team

Matt is the principal investigator (PI) for the Target Trials in Mental Health projects, which means he is responsible for the overall delivery and conduct of both the SilverCloud Target Trials and Target Therapies projects. 

Matt is a Senior Health Economist with expertise in economic evaluation; that is, estimating if new health and social care interventions are value for money compared to what is currently provided. Matt's other expertise is in mental health, trials, real-world data, causal inference, and patient-reported outcome measures. Matt’s array of expertise play a part in the overall nature of the Target Trials in Mental Health programme.

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Mike is a senior statistician at the University of Sheffield Clinical Trials Research Unit. He has almost 30 years experience as an applied statistician, working primarily in large scale randomised trials but also including non-randomised evaluations. He will work with the team to ensure that key principles of randomised trials are mirrored as far as possible, and will provide technical input into the analyses.

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Amy is a health economist with bedside training as a clinical pharmacist. She specialises in applying causal inference methods, including Target Trial Emulation, to analyse real-world healthcare data (e.g. hospital medical records) to evaluate treatment effectiveness. These techniques help answer “what-if” questions, such as what might have happened if patients had received different treatments, providing real-world evidence to fill gaps where clinical trials are not possible and supporting reimbursement and clinical decisions. 

Amy’s recent research focuses on methods for comparing treatment sequences or pathways using real-world data. She has extensive experience analysing large datasets, including US electronic health records, national surveys, and National Cancer Registries from England and Taiwan. 

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Robin works at the Sheffield Clinical Trials Research Unit (CTRU). He has experience of designing and implementing clinical trials.

Robin has been involved in a variety of National Institute for Health and Care Research (NIHR) or Medical Research Council (MRC) funded randomised controlled trials (RCTs), in a variety of clinical areas including occupational health, reproductive health, and adolescent scoliosis. Robin has also undertaken research focussing on clinical trials methodology. Robin will inform the Target Trial designs for the programme.

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Rowan is an econometrician. For the Target Trials in Mental Health programme, Rowan will be working with the other analysts to estimate the effectiveness of the different therapies and how well they work for various groups of people. Rowan’s other projects are in econometrics, health economics, environmental economics, and regional economics.

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Cindy has extensive experience of designing and implementing evaluations of complex health interventions in large multi-centre trials and other study designs. Cindy has been PI or co-applicant on 15 NIHR Health Technology Assessment, Public Health Research, Clinical Trials Unit (CTU) Efficient Trials call and Programme Grant for Applied Research grants related to trials and trials methodology to a total research cost of £12 million.  Cindy has published over 100 peer-reviewed research papers.  

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Jaime Delgadillo is a Professor of Clinical Psychology at the University of Sheffield. He has postgraduate qualifications in psychoanalysis and cognitive behavioural therapy, and 20 years of clinical experience as a psychotherapist. He has over 120 publications in scientific journals and book chapters. 

His current research examines the effectiveness and acceptability of new technologies such as digitally-enabled therapy, machine learning prediction models and artificial intelligence (AI) tools to support clinical decision-making. He is a member of the international Society for Psychotherapy Research, and associate editor of the society’s journal Psychotherapy Research.

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Nick joined the University of Sheffield in June 2008, having previously worked in the pharmaceutical industry and for a consultancy company. Nick is a health economist who has a particular interest in causal inference and target trial methodology. He is a member of the NICE Decision Support Unit and was a member of a NICE Appraisal Committee for five years. 

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Tony is a statistician and works with Matt and Rowan on the analysis of the routinely collected healthcare data. Tony's role will be to compare the effectiveness of the different therapies and how well they work for various groups of people. Tony has been using large, routinely collected datasets to generate evidence for over ten years, working across many different areas including: alcohol treatment services, cancer services, dentistry, urgent and emergency care, and education.

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Praveen is a Senior Research Fellow at the University of Sheffield. He has over 15 years’ experience in health economic modelling with over 100 publications and a Scopus h-index of 26. He will lead the health economic modelling work for both models to be designed for the SilverCloud Target Trials (i.e. the health economic model of depression, and the model of anxiety disorder), and will support a health economic research associate to develop the cost-effectiveness / budget-impact models.

Rob is an Associate Professor of Mental Health Data Science in the Department of Clinical, Educational and Health Psychology at UCL. Rob has extensive experience in the use of large healthcare datasets, where he has supported a number of evaluations of national treatment programmes. Rob has worked closely with NHS Talking Therapies for anxiety and depression services, supporting and advising teams how to use locally collected data to inform service improvement and research initiatives.

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Josh is an Associate Professor in Clinical Psychology within the Centre for Outcomes and Effectiveness Research at UCL. Josh’s role within Talking Therapies for anxiety and depression services has changed numerous times over the years, such that Josh now leads on research for the services and runs the UCL University Clinic. 

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Steve is Head of Department for Clinical, Educational and Health Psychology at UCL, and Director of the National Collaborating Centre for Mental Health (NCCMH). As a Consultant Clinical Psychologist in the NHS, he has set up, managed and evaluated many mental health services across the UK. 

Steve has directed mental health policy, including through his leading role on the development of NICE guidelines and informing the recent Community Mental Health Framework. Steve has also led investigations of complex health care interventions, including a recently completed NIHR Programme Grant evaluating the clinical and cost-effectiveness of Open Dialogue in NHS settings.

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Jae is a Research Fellow in the Department of Clinical, Educational and Health Psychology at UCL. She will mainly work as a data architect alongside Rob on this project and support data analysis. Jae has substantial experience in managing and analysing large, complex healthcare datasets including from national NHS Talking Therapies for anxiety and depression services, hospital records, and large cohort studies. 

Rachel works with George at the mental health research charity, The McPin Foundation. Their role is to oversee public involvement across the project, ensuring that the work is meaningful, accessible and effective for those who it intends to affect: service users themselves. Rachel works from a lived experience perspective, having accessed NHS talking therapies for social anxiety and OCD. Rachel will support George to coordinate the Lived Experience Advisory Panel.

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George works with Rachel at the mental health research charity, the McPin Foundation. Their role is to oversee public involvement across the project, ensuring that the work is meaningful, accessible and effective for those who it intends to affect: service users themselves. George works from a lived experience perspective, having accessed the SilverCloud internet-delivered CBT platform for anxiety.

Sebastian is Chartered Health Psychologist and Assistant Professor at Northumbria University whose research focuses on the intersection between Health Psychology and Implementation Science. He has a wealth of expertise in supporting the implementation of service innovations into health and social care practice. 

Sebastian will lead the implementation work package, which will explore barriers and facilitators of internet-based cognitive behavioural therapy (iCBT) within the NHS and co-develop tailored strategies to increase the spread and adoption of iCBT in routine care.

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Tim is a medical sociologist. He undertakes research that seeks to understand the everyday, taken-for-granted, aspects of medical, health and social care work. In this project, he will work with Sebastian to explore how best to roll out internet-based cognitive behavioural therapy (iCBT) across more NHS services.  

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Angel Enrique holds a PhD in Clinical Psychology and is currently working as a Senior Researcher at Amwell. In his role at Amwell, he conducts research studies to ensure SilverCloud by Amwell’s programmes meet the evidence standards from regulatory bodies, including the NICE guidelines in the UK. 

As part of this study, Angel holds main responsibility for the execution of Amwell’s duties and tasks and he also co-leads several work-packages including the commercialisation and the dissemination of the findings. 

Selin is a Digital Health Scientist at Amwell and a psychotherapist with 10 years of experience. She holds a PhD in Psychology and has dedicated her career to the digital health field, with a particular focus on the mixed-methods research.

She is interested in the effectiveness and acceptability of digital interventions for chronic health conditions and common mental health disorders, such as anxiety and depression. In this project, she will work alongside Angel and Daniel on the implementation and commercialisation work packages.

Dan is the Director of Research at Amwell. Dan leads the strategy and vision for the Amwell Research team, as well as leading on the conduct of various research endeavours. He holds a PhD in psychology from Trinity College Dublin. 

Dan is deeply passionate about the intersection between digital mental health interventions and implementation science, which means understanding barriers and facilitators around the appropriate utilisation of these interventions within specific contexts. 

As part of this project, Dan will collaborate on the work package on implementation science, given his expertise in the field. 

Annemijn has more than 25 years' experience in healthcare marketing across a range of different areas, including women’s health, pharmaceuticals and latterly in software as a medical device. Annemijn works at Hardian Health, an expert health technology consultancy supporting the project, and will be leading on the market strategy work in the project. This will focus on in-depth market research and analysis to work out how best to maximise the uptake and adoption of the Silvercloud technology in the NHS. 

Felicity is a medical doctor and biomedical engineer and works alongside Annemijn and the team at Hardian Health. Felicity is supporting Annemijn on the market strategy work package. She will be working collaboratively with the rest of the market strategy team to map the clinical pathway and make sure findings and recommendations are grounded within the wider clinical picture. 

Lauren is an Operations Support Officer in the School of Medicine and Population Heath at the University of Sheffield where she provides administrative support to research projects in the Heath Economics and Decision Science section. She will be providing wide-ranging support to the project teams, working closely with Emma.

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Emma is working with Lauren Hartley to support the Target Therapies and SilverCloud project meetings, having provided admin support to research projects in the Health Economics and Decision Science (HEDS) section at the University of Sheffield for the last five years. Emma's background is in administration in education and the voluntary sector, supporting senior staff, managing websites and member databases, and organising courses and events. 

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Anne works in the School of Medicine and Population Health at the University of Sheffield where she provides administrative and communications support to the Sheffield Addictions Research Group. She has a background in website management and digital communications in the NHS and third sector. Anne designed, built and maintains the Target Trials in Mental Health website.

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